VDR is a gene which encodes a vitamin-D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene, the rs2228570 (FokI polymorphism), is associated with lower bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of on- and off occupancy of the VDRE by the two components, and it is influenced by chromosomal location and binding preferences for certain hormones. Microarray studies of human cells indicate that more than 100 genes have an identifiable VDRE within their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) can be an archive of data and documents relevant to legal transactions, business, or proceedings. Viewing, downloading, or printing are restricted. It is accessed via a central server as well as an extranet connection, which is an Internet connection that has restricted access to allow controlled login time periods during which users are able to access the documents and data.
VDRs are primarily used by investment banks and businesses involved in mergers and acquisitions. They must be able to share information in a transparent way with potential investors or https://www.gescheftmarketing.de/2021/07/05/erwerb-von-wissen-und-geschaeftsrichtung-durch-vdr/ buyers. Due diligence can also require a substantial amount of data. Life science companies also utilize VDRs to store everything from clinical trials results to HIPAA documentation.